Development and Research of Force Field for Intrinsically Disordered Proteins-Associate Prof.Chen Hai-Feng, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
Project:  Development and Research of Force Field for Intrinsically Disordered Proteins
Abstract:  Intrinsically disordered proteins (IDPs) or intrinsically disordered protein regions comprise a large portion of eukaryotic proteomes (between 35% and 51%). These IDPs were found to link with cancer and various other diseases. However, widely used additive force field parameter sets are insufficient in quantifying the structural properties of IDPs. Therefore, we explored to a systematic correction of a base additive force field parameter set to correct the biases that was first demonstrated in simulations with the base parameter set. This project will build a new force field for IDPs. Furthermore, this force field will deeply improve the research of structure and function for IDPs and drug design based on IDPs.
Research team: 
  1. Lead PI: Chen Hai-Feng, Associate Professor, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  2. Ye Wei, PHD Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  3. Zhang Jin-Mai, PHD Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  4. Jiang Cheng, Graduate Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  5. Yang Jing-Xu, Graduate Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  6. Wang Wei, Graduate Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology
  7. Yu Qin-Feng, Graduate Student, Department of Bioinformatics and Biostatistics, College of Life Science and Technology

上一条:Thousand Crop Genome Project 下一条:Electron properties of DNA molecular systems and organic nanomaterials –Associate Prof. Ding Guo-Hui, Department of Physics and Astronomy

Copyright ©2013 SJTU Network & Information Center All rights reserved.